Winnipeg-Jerusalem Collaborative Projects Year 1 Summary

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Natural Killer CellsDr. Frank Plummer's team at The University of Manitoba and Dr. Ofer Mandelboim's team at The Institute for Medical Research Israel-Canada (IMRIC) at Hebrew University are in the process of completing their first year of collaborative research. They have also been working with the University of Nairobi, Kenya, in their investigations into "Natural Killer Cells" and how the mechanisms of these cells can be used in the fight against HIV/AIDS.



In the Pumwani District of Majengo, Nairobi, 3000 women are enrolled in the HIV/AIDS study, where disease progression, correlates, and genetic factors are being investigated. Of interest, 10% of women show resistance to HIV.

The following are the components of the HIV/AIDS Collaborative Project, along with some of the research students involved:

Defining the Role(s) of NK Cells in Mediating Resistance to HIV

  1. How Host Genetics May Play a Role - certain alleles are associated with resistance to HIV infection.
  2. NK/DC Interaction - evaluating the differences in Natural Killer/Dendritic Cell interactions in resistant individuals compared with HIV positive or negative people.
  3. NK Receptor and microRNA studies - isolating T cells from women who are HIV positive, negative, and resistant, and testing the ability of NK cells to recognize them and interact with/kill them.

Ghadiall - Sivro - Stanietsky

Year 1 Results: NK/DC Interaction Study

  • Study completed
  • Interesting results demonstrating altered interactions in individuals resistant to HIV
  • Manuscript of results prepared and submitted

Year 2 Projects:

  • MicroRNA Project will be the primary research focus for 2010-2011
  • Continue genetics projects already underway
  • Sequence NCRs from individuals of different backgrounds
  • More exchanges between senior investigators and trainees between Israel, Manitoba, & Kenya
  • Further analysis and publication of results
  • Brainstorm for future projects to collaborate on

Nairobi participants and Adrienne Meyers

 

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